CL-387785 - CAS# 194423-06-8 60102 Molecular Weight: 610

Molecular Weight: 610

Chemical Name:  5-((5-chloro-1H-pyrrolo[2

protein kinase C inhibitor LXS196 binds to and inhibits PKC

losartan carboxylic acid is more potent and has a longer duration of action than losartan

Nature Biotechnology 27

CL-387785 - CAS# 194423-06-8 60102 Molecular Weight: 610CL 387785, CAS No. 194423 06 8, also known as EKI 785 , is a n irreversible inhibitor of EGF receptor (EGFR) kinase activity in vivo (IC50 = 250 490 pM). CL 387785 covalently bound to EGF R. It also specifically inhibited kinase activity of the protein (IC50 = 370+ 120 pM), blocked EGF stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31 125 nM) primarily in a cytostatic manner in